Immune Parameters to Consider When Choosing T-Cell Receptors for Therapy

Immune Parameters to Consider When Choosing T-Cell Receptors for Therapy

T-cell receptor (TCR) therapy has arrived as a realistic treatment option for many human diseases. TCR gene therapy allows for the mass redirection of T-cells against a defined antigen while high affinity TCR engineering allows for the creation of a new class of soluble drugs. However, deciding which TCR blueprint to take forward for gene therapy or engineering is difficult. More than one quint...

Factors to consider when choosing an alignment system

A lthough an economic analysis will usually show that process-yield improvements and cycletime considerations have a far larger effect on the total cost of ownership, price is usually seen as the most important consideration when choosing an alignment system. Yet price should not be the single determining factor. True, system improvements to increase coupling yield are limited by prices that th...

Creating a Data Analysis Plan: What to Consider When Choosing Statistics for a Study.

Choosing a Model for eConsult Specialist Remuneration: Factors to Consider

Electronic consultation (eConsult) is an innovative solution that allows specialists and primary care providers to communicate electronically, improving access to specialist care. Understanding the cost implications of different remuneration models available to pay specialists is of critical importance as adoption of these services continues to increase. We used data collected through the Champ...

Points to consider when choosing a biopsy method in cases of pleurisy of unknown origin.

Blind pleural needle biopsy and diagnostic thoracoscopy are procedures sometimes used in the work-up of a patient with pleural effusion of unknown origin. We reviewed 203 diagnostic thoracoscopies in patients with malignant pleural effusion to show the different location of pleural metastasis, some out of the reach of blind needle biopsy. Based on these data, we find diagnostic thoracoscopy a s...